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[Acute toxicity of liver targeting mitoxantrone-nanospheres]
Hua Xi Yi Ke Da Xue Xue Bao = Journal of West China University of Medical Sciences = Huaxi Yike Daxue Xuebao
|March 1, 1995
Abstract:
The experimental result of acute toxicity of liver targeted drug delivery system-mitoxantrone-polybutylcyanoacrylate-nanospheres (DHAQ-PBCA-NS) in mice is reported. The results showed that the acute toxicity of DHAQ-PBCA-NS i.v. in mice was lower than that of DHAQ (LD50 = 16.9 +/- 3.9 mg/kg). The cells of the heart, liver, spleen, kidney and lung had no pathological change. It has been shown that mitoxantrone-nanospheres have some value of application.