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[Steady-state characteristics and optimal dosage regimens for Michaelis-Menten elimination drugs]
Hua Xi Yi Ke Da Xue Xue Bao = Journal of West China University of Medical Sciences = Huaxi Yike Daxue Xuebao
|March 1, 1995
Abstract:
In this paper, for the nonlinear process of the Michaelis-Menten elimination drugs, we first workout an analytical expression of the drug concentration after n times of intravenous injection. Then we study the steady-state characteristics of multiple intravenous dosing and give the analytical expressions to the steady-state drug concentration, the maximum, the minimum, the average drug concentration at steady state, the fraction reaching plateau concentration and the accumulation coefficient. Their application to the formation of the optimal dosage regimen is also discussed.