Related Experiment Video
Updated: Aug 15, 2026
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Basal cell carcinoma and lifestyle characteristics
W J Sahl1, S Glore, P Garrison
1West River Dermatology, Rapid City, SD 57701, USA.
International Journal of Dermatology
|June 1, 1995
Summary
This study found no link between lifestyle factors like sun exposure, alcohol, or smoking and basal cell carcinoma (BCC). However, higher caffeine intake was observed in BCC patients, suggesting a potential dietary influence.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- Basal cell carcinoma (BCC) etiology is influenced by various lifestyle factors.
- Previous research explored smoking, alcohol, diet, and sun exposure.
- This study uniquely examines lifestyle influences in BCC patients undergoing Mohs micrographic surgery.
Purpose of the Study:
- To investigate case-controlled lifestyle factors in basal cell carcinoma.
- To compare lifestyle characteristics between BCC patients and cancer-free controls.
Main Methods:
- Case-control study design.
- Cases: Basal cell carcinoma patients referred for Mohs surgery.
- Controls: Cancer-free individuals from a dermatology clinic, matched for age, sex, and skin type.
Main Results:
- No significant associations found for sun exposure, alcohol consumption, or smoking.
- Dietary factors (fat, fiber, vitamins A, C, beta-carotene, selenium) showed non-significant trends.
- Higher caffeine consumption was noted in the basal cell carcinoma group.
Conclusions:
- Findings align with previous research on antioxidant consumption as a protective factor for basal cell carcinoma.
- Elevated caffeine intake was a distinguishing characteristic in BCC patients.
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Related Concept Videos
02:40Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
01:12Renewal of Skin Epidermal Stem Cells
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:21Barrett Esophagus-I: Introduction
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
01:20Lifestyle Factors and Health
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...