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Pancreatic panniculitis

P R Dahl1, W P Su, K C Cullimore

  • 1Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.

Journal of the American Academy of Dermatology
|September 1, 1995
PubMed
Summary
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Pancreatic panniculitis, a rare condition, presents with fat necrosis and can precede pancreatic disease diagnosis. Histopathology reveals characteristic "ghost cells" and granulomatous changes.

Area of Science:

  • Dermatology
  • Gastroenterology
  • Pathology

Background:

  • Pancreatic panniculitis is a rare condition characterized by fat necrosis.
  • It occurs in patients with underlying pancreatic diseases.

Purpose of the Study:

  • To investigate the clinical and histopathologic features of pancreatic panniculitis.
  • To understand its presentation and association with pancreatic pathology.

Main Methods:

  • Retrospective review of 11 patients diagnosed with pancreatic panniculitis.
  • Analysis of clinical presentations and histopathologic findings.

Main Results:

  • Subcutaneous fat necrosis preceded pancreatic disease diagnosis in 5 patients.
  • Underlying causes included pancreatitis and pancreatic carcinoma.

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  • Distinctive histopathologic findings included "ghost cells" in acute lesions and granulomatous changes in chronic lesions.

    • Conclusions:

    • Pancreatic panniculitis exhibits unique clinical and histopathologic features.
    • These findings can serve as early indicators of pancreatic disease.