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A new mutant rat with turning behavior (Tur)

K Yamazaki1, T Mikami, A Kawaguchi

  • 1Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.

The Journal of Heredity
|July 1, 1995
PubMed
Summary

A novel rat mutation causes abnormal tail-chasing behavior in response to stimuli. This autosomal dominant trait, named "turning" (Tur), exhibits incomplete penetrance and was mapped to a new congenic strain.

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Area of Science:

  • Genetics
  • Neuroscience
  • Animal Behavior

Background:

  • A spontaneous mutation arose in a closed colony of Slc: SD rats.
  • Affected rats exhibit abnormal circling behavior, particularly in response to external stimuli.

Purpose of the Study:

  • To characterize a newly identified rat mutant with abnormal behavior.
  • To determine the genetic basis and inheritance pattern of the observed trait.

Main Methods:

  • Behavioral observation of affected rats from 4-5 weeks of age.
  • Gross and light microscopic examination of brain structures (cerebrum, cerebellum) and semicircular canals.
  • Genetic crosses to analyze inheritance patterns and penetrance.
  • Establishment of a congenic strain (WKY/Eis-Tur).

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Main Results:

  • Affected rats displayed tail-chasing behavior triggered by stimuli like sound or vibration.
  • No gross or microscopic abnormalities were detected in the brain or vestibular system.
  • The trait is controlled by an autosomal dominant gene (Tur) with 78.0% incomplete penetrance in the WKY genetic background.

Conclusions:

  • A new autosomal dominant gene, Tur, causes abnormal circling behavior in rats.
  • The mutation affects behavior without apparent structural brain or vestibular defects.
  • A congenic strain, WKY/Eis-Tur, was developed for further study of this genetic trait.