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Single- and multiple-dose-response relationships of beta-carotene in cystic fibrosis
D N Homnick1, C R Spillers, S R Cox
1Department of Pediatrics, Michigan State University, Kalamazoo Center for Medical Studies 49008, USA.
The Journal of Pediatrics
|September 1, 1995
Abstract:
Concentrations of carotenoids are low in patients with cystic fibrosis (CF) and are associated with essential fatty acid deficiency and increased markers of inflammation. We conducted single- and multiple-dose studies of beta-carotene supplementation in patients with CF. Dose-proportional increases in beta-carotene concentrations were found, although clearance was independent of dose. Large doses of beta-carotene were necessary to achieve normal plasma levels.