Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Screening for QT prolongation using a new exponential formula

S Aihoshi1, M Yoshinaga, M Nakamura

  • 1Department of Pediatrics, Faculty of Medicine, Kagoshima University, Japan.

Japanese Circulation Journal
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three types of Gi alpha protein of the guinea-pig lung: cDNA cloning and analysis of their tissue distribution.

Biochimica et biophysica acta·1992
Same author

Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor.

FEBS letters·1992
Same author

Endothelium-dependent vasodilation is augmented by angiotensin converting enzyme inhibitors in healthy volunteers.

Journal of cardiovascular pharmacology·1992
Same author

High-performance liquid chromatographic determination of fatty acid binding proteins in rat liver with fluorescence detection.

The Analyst·1992
Same author

[Primary adenocarcinoma of the male urethra with high CA125 level: a case report].

Hinyokika kiyo. Acta urologica Japonica·1992
Same author

Similarity of the constituents between glomerular arteriolar and mesangial lesions in experimental diabetes.

Diabetes research and clinical practice·1992
Same journal

Vasospastic total occlusion at the left main tract in a single coronary artery.

Japanese circulation journal·2002
Same journal

Spontaneous onset of torsade de pointes in long-QT syndrome and the role of sympathovagal imbalance.

Japanese circulation journal·2002
Same journal

'No-Touch' isolation procedure for ruptured mycotic abdominal aortic aneurysm.

Japanese circulation journal·2002
Same journal

Th1/Th2 balance alteration in the clinical course of a patient with acute viral myocarditis.

Japanese circulation journal·2002
Same journal

Vagal stimulation prior to atrial rapid pacing protects the atrium from electrical remodeling in anesthetized dogs.

Japanese circulation journal·2002
Same journal

Differences in the expression of protein kinase C isoforms and its translocation after stimulation with phorbol ester between young-adult and middle-aged ventricular cardiomyocytes isolated from Fischer 344 rats.

Japanese circulation journal·2002
See all related articles

This study introduces an exponential correction for QT interval (eQTc) to screen children for heart rate abnormalities. The new method identified more cases of QT prolongation than traditional criteria.

Area of Science:

  • Pediatric Cardiology
  • Electrocardiography
  • Public Health Screening

Background:

  • The QT interval is a critical measure of cardiac repolarization.
  • Conventional QT correction methods can be inaccurate in children due to heart rate variability.
  • Accurate screening for QT prolongation is essential for identifying children at risk of arrhythmias.

Purpose of the Study:

  • To evaluate the utility of a novel exponential correction formula for QT interval (eQTc) in screening school-aged children.
  • To compare the effectiveness of eQTc screening against conventional QT correction criteria.
  • To identify potential cases of QT prolongation missed by standard screening methods.

Main Methods:

  • Prospective screening of 14,227 school-aged children.

Related Experiment Videos

  • Application of an exponential formula (eQTc = QT interval / RR interval^0.31) with age- and sex-specific criteria.
  • Comparison of eQTc results with conventional QT correction criteria.

    • Main Results:

    • 13 children were detected with abnormally prolonged eQTc.
    • All children with abnormal conventional QTc also had abnormal eQTc.
    • Six cases of QT prolongation were identified by eQTc that would have been missed by conventional criteria, including a case with deaf parents.

    Conclusions:

    • Exponential correction of the QT interval (eQTc) is a valuable tool for large-scale prospective screening in pediatric populations.
    • eQTc demonstrates improved sensitivity in detecting QT prolongation, particularly in children with heart rates >75 bpm.
    • This novel method enhances the identification of children requiring further cardiac evaluation.