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Determination of fluconazole concentrations in the prostatic and seminal vesicle fluid (split ejaculate)
P Schramm1, A Wildfeuer, E Sarnow
1Universitätshautklinik Mainz, Germany.
Mycoses
|November 1, 1994
Summary
This study measured fluconazole (a systemic antifungal) levels in split ejaculate and serum of healthy volunteers. Ejaculate fluconazole concentrations mirrored serum levels, suggesting prostate drug penetration.
Area of Science:
- Pharmacology
- Urology
- Infectious Diseases
Background:
- Fluconazole is a widely used systemic antifungal agent.
- Understanding drug distribution in urogenital tissues is crucial for treating infections.
Purpose of the Study:
- To determine fluconazole concentrations in split ejaculate fractions.
- To compare ejaculate fluconazole levels with serum concentrations.
- To infer prostatic fluconazole concentrations.
Main Methods:
- Seven healthy volunteers received oral fluconazole (200 mg daily) for 5 days.
- Ejaculate samples were collected and divided into two fractions.
- Serum samples were collected concurrently for drug level analysis.
Main Results:
- Fluconazole concentrations were measured in both ejaculate fractions and serum.
- Drug levels in both ejaculate fractions were comparable to serum concentrations.
- The first ejaculate fraction, originating from the prostate, showed similar fluconazole levels to serum.
Conclusions:
- Fluconazole distributes effectively into the ejaculate.
- Prostatic fluconazole concentrations are likely similar to serum levels.
- This supports fluconazole's potential efficacy in treating prostatic or genitourinary fungal infections.