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CCKB receptor activation protects CA1 neurons from ischemia-induced dysfunction in stroke-prone spontaneously
1Division of Pharmacology, Shionogi & Co., Ltd., Osaka, Japan.
Neuroscience Letters
|May 19, 1995
Abstract:
We examined the effect of cholecystokinin octapeptide sulfated type (CCK-8S) on dysfunction of CA1 pyramidal neurons induced by in vitro ischemic insult in hippocampal slices of stroke-prone spontaneously hypertensive rats (SHRSP). CCK-8S shortened the time required for partial recovery from block of a population spike produced by ischemia. Furthermore, CCK-8S reduced ischemic insult-induced accumulation of K+ in extracellular space. Suppression of the K+ conductance by the CCKB receptor activation is suggested to contribute to neuroprotection by CCK-8S.