Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multicenter experience with a bipolar tined polyurethane ventricular lead

D L Hayes1, K J Graham, M Irwin

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Pacing and Clinical Electrophysiology : PACE
|May 1, 1995
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Way It Was.

Annual review of microbiology·2019
Same author

DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2019
Same author

The Surgical Management of Ruptured Abdominal Aortic Aneurysm: A Ten -Year Experience.

The Australian and New Zealand journal of surgery·2017
Same author

Socioeconomic status and lifestyle behaviours in cancer survivors: smoking and physical activity.

Current oncology (Toronto, Ont.)·2017
Same author

A Supernova at z = 0.458 and Cosmologya.

Annals of the New York Academy of Sciences·2015
Same author

Reproductive biology of the greeneye spurdog Squalus chloroculus (Squaliformes, Squalidae).

Journal of fish biology·2015

The Medtronic 4004/4004M ventricular pacing lead shows an unacceptable 14.1% failure rate within 4 years due to insulation issues. Pacemaker-dependent patients may require lead replacement.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Device Technology

Background:

  • Bipolar tined polyurethane ventricular pacing leads are crucial for cardiac rhythm management.
  • Assessing the long-term reliability of implantable pacing leads is essential for patient safety and device efficacy.

Purpose of the Study:

  • To determine the failure rate of the Medtronic 4004/4004M bipolar tined polyurethane ventricular pacing lead.
  • To identify the clinical manifestations and probability of lead failure within a 4-year period.

Main Methods:

  • A multicenter study involving seven centers in the United States and Canada.
  • Implantation of 586 Medtronic 4004/4004M pacing leads.
  • Kaplan-Meier survival analysis to estimate lead failure probability, focusing on insulation-related failures.

Related Experiment Videos

Main Results:

  • The estimated cumulative failure rate of the Medtronic 4004/4004M lead within 4 years was 14.1% (95% CI: 8.5%-19.3%).
  • Observed failures included sensing abnormalities, failure to capture, early battery depletion, and decreased impedance.
  • Failures were specifically linked to insulation problems.

Conclusions:

  • The observed failure rate of the Medtronic 4004/4004M pacing lead is unacceptably high.
  • Consideration should be given to replacing this lead in pacemaker-dependent patients.
  • Close monitoring of non-dependent patients with this lead is recommended.