Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet-collagen interactions

B Kehrel1

  • 1Department of Internal Medicine, University of Münster, Germany.

Seminars in Thrombosis and Hemostasis
|January 1, 1995
PubMed
Summary

Vessel wall collagens, particularly types I and III, promote platelet adhesion and aggregation. Specific collagen fragments and anti-platelet proteins from animals can modulate these interactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Diagnosis of inherited diseases of platelet function. Interdisciplinary S2K guideline of the Permanent Paediatric Committee of the Society of Thrombosis and Haemostasis Research (GTH e. V.)].

Hamostaseologie·2014
Same author

Immunochemical localization of phenylalanine ammonia-lyase and chalcone synthase in anthers.

Planta·2013
Same author

Platelet receptors for collagens.

Platelets·2010
Same author

A simple and rapid immunomagnetobead technique for the analysis of platelet glycoprotein deficiencies.

Platelets·2010
Same author

Platelet analysis using flowcytometric procedures.

Platelets·2010
Same author

ADP-coupled integrin regulation by the extracellular redox system.

Pathophysiology of haemostasis and thrombosis·2006

Area of Science:

  • Biochemistry
  • Vascular Biology
  • Hematology

Background:

  • Collagens in the subendothelium are key determinants of vessel wall thrombogenicity.
  • Nineteen distinct collagen types are known, with at least nine found in vessel walls.
  • Collagen molecules consist of three chains in a triple-helical conformation, some with non-collagenous domains.

Purpose of the Study:

  • To investigate the role of specific collagen types and their fragments in platelet adhesion and aggregation.
  • To identify platelet-reactive sites within collagen molecules.
  • To explore substances that interfere with platelet-collagen interactions.

Main Methods:

  • Characterization of collagen types and their presence in the vessel wall.
  • Analysis of platelet adhesion and aggregation using collagen fragments (CNBr-peptides).
  • Identification of naturally occurring anti-platelet substances.

Main Results:

  • Monomeric and fibrillar collagens support platelet adhesion; native triple-helical structure is required for aggregation and secretion.
  • Specific sites within alpha 1(I) and alpha 1(III) collagen chains mediate platelet aggregation.
  • The cyanogen bromide fragment alpha 1(I)CB3 strongly supports platelet adhesion, while alpha 1(III)CB4 is highly aggregatory.

Conclusions:

  • Collagen types I and III contain critical sites for platelet adhesion and aggregation.
  • Understanding these interactions is crucial for vascular biology and thrombogenicity.
  • Naturally occurring inhibitors of platelet-collagen interactions exist, offering potential therapeutic insights.

Related Experiment Videos