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Desmopressin effect on acetylsalicylic acid impaired platelet function
K H Beck1, P Mohr, U Bleckmann
1Department of Transfusion Medicine and Hemostaseology, Klinikum, Philips University, Marburg, Germany.
Seminars in Thrombosis and Hemostasis
|January 1, 1995
Summary
Desmopressin (DDAVP) shortens bleeding times caused by aspirin (ASA) by increasing functional von Willebrand factor (vWF). DDAVP may also directly impact platelet function, inhibiting aggregation and release reactions.
Area of Science:
- Pharmacology
- Hematology
- Clinical Medicine
Background:
- Aspirin (acetylsalicylic acid, ASA) is known to prolong bleeding times.
- Desmopressin (DDAVP) is a synthetic analog of vasopressin used to treat bleeding disorders.
Purpose of the Study:
- To investigate the mechanism by which DDAVP shortens ASA-induced prolonged bleeding times.
- To elucidate the role of von Willebrand factor (vWF) and platelet function in DDAVP's hemostatic effects.
Main Methods:
- A randomized controlled trial involving 16 healthy subjects.
- Administration of ASA followed by DDAVP.
- Measurement of in vivo and in vitro bleeding times.
- Analysis of plasma vWF antigen and activity, platelet aggregation, and thromboxane levels.
Main Results:
- A strong inverse correlation was observed between bleeding times and Ristocetin cofactor activity (vWf R:Co), indicating plasma vWF involvement.
- Plasma thromboxane levels did not appear to mediate DDAVP's effect.
- DDAVP administration led to reduced beta-thromboglobulin (beta-TG) in plasma, suggesting inhibition of platelet release reaction.
Conclusions:
- DDAVP effectively shortens ASA-induced bleeding times, primarily through enhancing plasma von Willebrand factor activity.
- DDAVP may also exert direct effects on platelets, potentially inhibiting aggregation and release mechanisms.