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Basic fibroblast growth factor may repair experimental cerebral aneurysms in rats
K Futami1, J Yamashita, O Tachibana
1Department of Neurosurgery, Kanazawa University School of Medicine, Japan.
Stroke
|September 1, 1995
Summary
Basic fibroblast growth factor (FGF) promotes smooth muscle cell proliferation in rat cerebral aneurysms. High doses of FGF induced significant intimal thickening, indicating its role in aneurysmal lesion development.
Area of Science:
- Vascular Biology
- Regenerative Medicine
- Neovascularization Research
Background:
- Cerebral aneurysms involve complex cellular changes.
- Endothelial and smooth muscle cell behavior is critical in aneurysm progression.
Purpose of the Study:
- To investigate the effect of basic fibroblast growth factor (FGF) on experimental cerebral aneurysms.
- To determine if FGF induces proliferation of endothelial and smooth muscle cells in aneurysmal lesions.
Main Methods:
- Experimental cerebral aneurysms were induced in rats.
- Basic FGF was administered intravenously at low and high doses.
- Aneurysmal lesions were analyzed histologically and via immunohistochemistry.
Main Results:
- High-dose basic FGF induced significant intimal thickening in early aneurysmal lesions.
- Proliferated cells in thickened areas were identified as smooth muscle cells.
- Low-dose FGF and control groups showed no significant intimal thickening.
Conclusions:
- Exogenous basic FGF stimulates smooth muscle cell proliferation within aneurysmal lesions.
- Basic FGF plays a role in the cellular response of aneurysmal walls.