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Multidrug resistant non-typhoidal Salmonella infections
U S Udgaonkar1, R D Kulkarni, V A Kulkarni
1Department of Microbiology, Government Medical College, Miraj, India.
Tropical Doctor
|July 1, 1995
Summary
Multi-drug resistant non-typhoidal Salmonella infections predominantly affected children in Sangli. Salmonella typhimurium was the most common cause, with high mortality from septicemia in infants.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Pediatrics
Background:
- Non-typhoidal Salmonella (NTS) infections pose a significant public health challenge, particularly in vulnerable populations.
- The emergence of multi-drug resistant (MDR) strains necessitates ongoing surveillance and characterization.
Purpose of the Study:
- To investigate the prevalence and characteristics of MDR non-typhoidal Salmonella isolates from clinical samples.
- To identify the predominant serotypes and clinical presentations associated with these infections.
Main Methods:
- Retrospective analysis of clinical isolates over a 2-year period at Government General Hospital, Sangli.
- Microbiological identification and serotyping of Salmonella isolates.
- Review of patient demographics and clinical outcomes.
Main Results:
- Twenty-eight cases of MDR NTS infections were identified.
- The pediatric age group accounted for 93% of cases.
- Salmonella typhimurium (86%) was the predominant isolate, followed by Salmonella newport (14%).
- Gastroenteritis was the most common clinical presentation.
- Septicemia in infants under 1 month of age had a 100% mortality rate.
- Two cases of meningitis were also reported.
Conclusions:
- MDR non-typhoidal Salmonella infections represent a significant threat to pediatric patients, especially neonates.
- Salmonella typhimurium is a major causative agent, highlighting the need for targeted antimicrobial stewardship.
- Prompt diagnosis and management are crucial, particularly for invasive infections like septicemia and meningitis.