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"Watershed" infarction in sickle cell disease

D Enzmann, G F Gates

|February 1, 1976

Summary

Sickle cell disease can cause watershed infarction in children, a pattern clearly seen on brain scintigraphy. Computed tomography scans may show fewer changes than radionuclide imaging in these cases.

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Area of Science:

Neurology
Pediatrics
Radiology

Background:

Sickle cell disease is a genetic blood disorder that can lead to various complications, including stroke.
Watershed infarcts occur in areas of the brain supplied by major arteries, often due to reduced blood flow.

Observation:

A seven-year-old female patient with sickle cell disease presented with neurological symptoms.
Brain scintigraphy revealed a classical watershed infarction pattern.

Findings:

The radionuclide imaging demonstrated characteristic findings of watershed infarction.
Computed tomography (CT) showed minimal abnormalities, contrasting with the scintigraphy results.

Implications:

Brain scintigraphy can be a valuable tool for diagnosing stroke patterns in pediatric sickle cell disease patients.
Radiological findings in sickle cell disease-related stroke may vary, highlighting the importance of correlating different imaging modalities.

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