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Related Experiment Videos

Horizontal cells function normally in ethambutol-treated goldfish

J J Wietsma1, M Kamermans, H Spekreijse

  • 1Graduate School Neurosciences Amsterdam, Laboratory of Medical Physics and Informatics, University of Amsterdam, The Netherlands.

Vision Research
|June 1, 1995
PubMed
Summary

Ethambutol, a drug used to treat tuberculosis, causes red-green color vision defects. This study found that ethambutol does not induce dark adaptation in goldfish retinas, suggesting the vision defect originates elsewhere.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Pharmacology

Background:

  • Ethambutol, a tuberculostatic drug, is known to cause red-green color vision defects in humans and goldfish.
  • Previous research suggested these defects might stem from retinal changes, specifically dark adaptation, due to observed alterations in retinal cells.

Purpose of the Study:

  • To investigate the hypothesis that ethambutol induces dark adaptation in the goldfish retina.
  • To determine if ethambutol's effects on color vision originate in the horizontal cell layers of the retina.

Main Methods:

  • Examined the effects of ethambutol on horizontal cell receptive field size and spectral sensitivity in goldfish.
  • Assessed changes in spectral characteristics of horizontal cells after long-term ethambutol treatment.

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  • Evaluated the formation of spinules on horizontal cell dendrites, a marker for light adaptation.

    • Main Results:

    • Ethambutol caused only transient changes in horizontal cell receptive field size and spectral sensitivity.
    • No alterations in the spectral characteristics of horizontal cells were observed in long-term ethambutol-treated goldfish.
    • The formation of spinules, indicative of light adaptation, was unaffected by ethambutol treatment.

    Conclusions:

    • Ethambutol does not induce functional dark adaptation in goldfish horizontal cells.
    • The red-green color vision deficiency caused by ethambutol is unlikely to originate in the horizontal cell layers of the retina.