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Effect of 2-amino-4-phosphonobutyrate on ERG OFF-response after glycinergic and GABAergic blockade
E Popova1, P Kupenova, L Vitanova
1Department of Physiology, Medical Faculty, Sofia, Bulgaria.
Vision Research
|July 1, 1995
Abstract:
Superfusion with 200 microM 2-amino-4-phosphonobutyrate (APB) of dark and chromatically adapted frog eyecups caused marked potentiation of the ERG OFF-response (d-wave). Blockade of the glycinergic synapses by strychnine did not change this effect at all. Blockade of the GABAergic synapses by picrotoxin slightly diminished the effect of APB in chromatically-adapted eyes with isolated cones' activity, and did not change it in dark-adapted eyes. The results indicate that the action of APB on ERG OFF-response does not depend significantly on GABAergic and glycinergic neurotransmission in frog retina.