Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risks of perimenopausal fractures--a prospective population-based study

M Tuppurainen1, H Kröger, R Honkanen

  • 1Department of Obstetrics and Gynecology, University Hospital of Kuopio, Finland.

Acta Obstetricia Et Gynecologica Scandinavica
|September 1, 1995
PubMed
Summary

Previous fractures, low bone mineral density, and alcohol use increase fracture risk in perimenopausal women. Hormone replacement therapy shows a protective effect against fractures in this demographic.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65-71 years: a 3-year randomized population-based trial (OSTPRE-FPS).

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
Same author

Sister's fracture history may be associated with perimenopausal bone fragility and modifies the predictability of fracture risk.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2008
Same author

Association between functional capacity tests and fractures: an eight-year prospective population-based cohort study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2008
Same author

Red blood cell and tissue water content in experimental thermal injury.

Burns : journal of the International Society for Burn Injuries·2005
Same author

Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding.

Regulatory peptides·2005
Same author

Microdialysis for detection of dynamic changes in tissue histamine levels in experimental thermal injury.

Burns : journal of the International Society for Burn Injuries·2005

Area of Science:

  • Bone Health and Osteoporosis Research
  • Menopause and Women's Health
  • Fracture Prevention Strategies

Background:

  • Perimenopausal women are at increased risk for fractures due to hormonal changes and bone density loss.
  • Identifying modifiable and non-modifiable risk factors is crucial for effective fracture prevention in this population.

Purpose of the Study:

  • To investigate the associations between various potential risk factors and the occurrence of fractures in a cohort of perimenopausal women.
  • To identify key predictors of fracture risk and protective factors during the menopausal transition.

Main Methods:

  • A longitudinal study followed 3,140 women (mean age 53.4 years) for 2.4 years.
  • Axial bone densitometry (lumbar spine and femoral neck) was performed, and fracture occurrences were recorded.

Related Experiment Videos

  • Statistical analyses were used to assess the impact of risk factors like prior fractures, alcohol intake, and hormone replacement therapy (HRT).

    • Main Results:

    • 5.6% of women experienced fractures, with the wrist being the most common site.
    • Lower lumbar and femoral bone mineral density (BMD) were significantly associated with fracture cases (p < 0.0001).
    • Prior fracture history, higher alcohol intake, and early bilateral oophorectomy (<45 years) increased fracture risk, while HRT use was protective.

    Conclusions:

    • Former fracture history, low baseline BMD, and alcohol consumption are significant predisposing factors for fractures in perimenopausal women.
    • Hormone replacement therapy demonstrates a protective effect against fractures in this age group.
    • These findings highlight the importance of BMD assessment and lifestyle modifications for fracture prevention in perimenopausal women.