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Passive immunity to contagious bovine pleuropneumonia
Research in Veterinary Science
|November 1, 1975
Summary
Passive immunity can protect cattle against contagious bovine pleuropneumonia (CBPP). Serum from recovered cattle provided significant protection, while serum from susceptible cattle offered limited benefit against this Mycoplasma mycoides infection.
Area of Science:
- Veterinary Immunology
- Bovine Infectious Diseases
Background:
- Contagious bovine pleuropneumonia (CBPP) is a severe respiratory disease affecting cattle.
- Effective passive immunization strategies are crucial for controlling CBPP outbreaks.
Purpose of the Study:
- To evaluate the efficacy of passive immunity transfer using serum from recovered cattle for protection against CBPP.
- To compare the protective effects of serum from convalescent cattle versus susceptible cattle.
Main Methods:
- Cattle were divided into three groups: inoculated with serum from recovered CBPP cases, inoculated with serum from susceptible cattle, and an untreated control group.
- All groups were challenged with the virulent Mycoplasma mycoides (Gladysdale strain) via the in-contact method.
- Protection was assessed by monitoring survival rates post-challenge.
Main Results:
- Four out of five cattle receiving serum from recovered animals survived the CBPP challenge.
- In contrast, only three out of five cattle receiving serum from susceptible animals survived.
- All cattle in the untreated control group succumbed to the disease.
Conclusions:
- Passive transfer of serum from CBPP-recovered cattle confers significant protection against homologous challenge.
- Serum from susceptible cattle provides minimal to no protective benefit.
- This study highlights the potential of convalescent serum as a passive immunization tool against contagious bovine pleuropneumonia.