Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A system model for halothane closed-circuit anesthesia. Structure considerations and performance evaluation

P M Vermeulen1, J G Lerou, R Dirksen

  • 1Institute for Anesthesiology, University of Nijmegen, The Netherlands.

Anesthesiology
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ancillary investigations to diagnose parkinsonism: a prospective clinical study.

Journal of neurology·2014
Same author

Doxorubicin/cyclophosphamide with concurrent versus sequential docetaxel as neoadjuvant treatment in patients with breast cancer.

European journal of cancer (Oxford, England : 1990)·2013
Same author

Belgian recommendations on perioperative maintenance fluid management of surgical pediatric population.

Acta anaesthesiologica Belgica·2013
Same author

Flow cytometric immunobead assay for fast and easy detection of PML-RARA fusion proteins for the diagnosis of acute promyelocytic leukemia.

Leukemia·2012
Same author

Health status one year after TransInguinal PrePeritoneal inguinal hernia repair and Lichtenstein's method: an analysis alongside a randomized clinical study.

Hernia : the journal of hernias and abdominal wall surgery·2012
Same author

First trial reactions and habituation rates over successive balance perturbations in Parkinson's disease.

Neuroscience·2012
Same journal

The Time-out.

Anesthesiology·2026
Same journal

Evaluation of Post-block Hypersensitivity Using Quantitative Sensory Testing Before, During, and After Axillary Brachial Plexus Block Resolution in Healthy Volunteers.

Anesthesiology·2026
Same journal

The state of medical education research in Anesthesiology: Current landscape and future directions - An initiative of the Anesthesia Research Council.

Anesthesiology·2026
Same journal

Diagnostic Ultrasound-guided Focused Ultrasound-induced Noninvasive, Reversible Peripheral Nerve Blockade in an In Vivo Model of Acute Pain: A Proof-of-Concept Study.

Anesthesiology·2026
Same journal

S-Ketamine Reduces Risk of Postoperative Delirium: Comment.

Anesthesiology·2026
Same journal

Computed Tomography-Based Body Composition Assessment for Preoperative Cardiovascular Risk Prediction: A Prospective Cohort Study.

Anesthesiology·2026
See all related articles

A new anesthesia model accurately predicts halothane levels in closed-circuit systems. Version D' with nonpulmonary elimination and age-adjusted coefficients proved most reliable for clinical use.

Area of Science:

  • Anesthesiology
  • Pharmacokinetics
  • Mathematical Modeling

Background:

  • A physiologic model for closed-circuit inhalational anesthesia was previously validated for isoflurane.
  • An extended model incorporating nonpulmonary elimination improved accuracy for enflurane.
  • The model's performance for non-inert anesthetics like halothane required evaluation.

Purpose of the Study:

  • To quantify the predictive performance of four versions of a closed-circuit anesthesia model for halothane.
  • To evaluate the impact of nonpulmonary elimination and age-adjusted partition coefficients on model accuracy.

Main Methods:

  • Compared predicted and measured alveolar halothane concentrations in 53 patients.
  • Tested four model versions: A (no nonpulmonary elimination), D (nonlinear hepatic elimination), A' (age-adjusted coefficients), and D' (both nonpulmonary elimination and age-adjusted coefficients).

Related Experiment Videos

  • Calculated root mean squared error (rmse), bias, and scatter for prediction errors.

    • Main Results:

    • 53 patients underwent anesthesia with halothane over 61 hours, with 21,890 concentrations measured.
    • Version D' demonstrated the best performance with an rmse of 19.6 ± 7.2%, bias of 0.5 ± 15.9%, and scatter of 13.2 ± 3.5%.
    • This indicates high accuracy and reliability for Version D'.

    Conclusions:

    • The model version (D') incorporating nonpulmonary elimination and age-adjusted partition coefficients is accurate for halothane closed-circuit anesthesia.
    • This system model and its versions are valuable for predicting anesthetic dynamics (isoflurane, enflurane, halothane).
    • The model serves clinical, educational, and research applications.