Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p53 oncoprotein expression in cutaneous lymphoproliferations

M Beylot-Barry1, B Vergier, A DeMascarel

  • 1Service de Dermatologie, Centre Hospitalo-Universitaire de Bordeaux (France).

Archives of Dermatology
|September 1, 1995
PubMed
Summary

p53 overexpression is not found in common primary cutaneous lymphomas but is present in high-grade lymphomas, including those in HIV-infected individuals. Further research will clarify p53

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9.

Nature communications·2023
Same author

Clinical features associated with the invasive component in lentigo maligna of the head and neck: A retrospective study of 175 cases.

Annales de dermatologie et de venereologie·2022
Same author

CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells.

Nature communications·2021
Same author

Clinicopathologic analysis of trichoblastoma and comparison with nodular basal cell carcinoma.

Annales de dermatologie et de venereologie·2021
Same author

Lymph node and visceral progression without erythroderma or blood worsening in erythrodermic cutaneous T-cell lymphoma: nine cases.

The British journal of dermatology·2021
Same author

Lymphomatoid papulosis types D and E: a multicentre series of the French Cutaneous Lymphomas Study Group.

Clinical and experimental dermatology·2021

Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • p53 overexpression is noted in systemic lymphoproliferations.
  • This study investigates p53 expression in primary cutaneous lymphomas, a novel area of research.

Purpose of the Study:

  • To determine the prevalence and significance of p53 expression in various types of primary cutaneous lymphomas.
  • To explore potential correlations between p53 expression, lymphoma grade, and human immunodeficiency virus (HIV) status.

Main Methods:

  • p53 immunohistochemical detection using the DO7 monoclonal antibody.
  • Analysis of 54 cases of cutaneous lymphoproliferative disorders, including 37 primary cutaneous T- and B-cell lymphomas.

Main Results:

Related Experiment Videos

  • No p53 expression was observed in mycosis fungoides, pleomorphic T-cell lymphomas, low-grade B-cell lymphomas, or benign dermatoses.
  • p53 overexpression was detected in 10 high-grade primary cutaneous lymphomas (T- or B-cell origin), including immunoblastic, centroblastic, and anaplastic types.
  • p53 immunoreactivity was noted in lymphomatoid papulosis and, to a lesser extent, in epidermal keratinocytes.

    • Conclusions:

    • p53 overexpression is absent in common primary cutaneous lymphomas like epidermotropic T-cell lymphomas.
    • p53 immunoreactivity is associated with high-grade primary cutaneous lymphomas, irrespective of HIV infection status.
    • Further molecular studies are needed to link p53 overexpression to gene alterations and elucidate its role in cutaneous lymphoma development.