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Published on: August 26, 2012
Comparing transcriptional initiation by RNA polymerases I and III
E P Geiduschek1, G A Kassavetis
1Department of Biology, University of California at San Diego, La Jolla 92093-0634, USA.
Abstract:
We comment on the current understanding of transcriptional initiation by RNA polymerases I and III, and look for common modes of operation of these enzymes, emphasizing selected recent developments. These include definitive experiments on the constitution of the human RNA polymerase I transcription factor SL1/TIF-IB, the development of a genetic system for analyzing the function of RNA polymerase I in yeast, the elucidation of the structure of the human snRNA gene transcription factor SNAPc, and initial stages of mapping the protein-protein interactions involved in the assembly of transcriptional initiation complexes.
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