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Multiple primary lung cancers

M Ribet1, P Dambron

  • 1University of Lille, France.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|January 1, 1995
PubMed
Summary
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Multiple primary lung cancers are rare in resected tumors. Synchronous lung cancers indicate advanced disease, while metachronous lung cancers are often diagnosed late.

Area of Science:

  • Thoracic Surgery
  • Oncology
  • Pulmonary Medicine

Background:

  • Multiple primary lung cancers (MPLC) constitute a significant subset of lung malignancies.
  • Understanding the distinction between synchronous and metachronous MPLC is crucial for patient management and prognosis.

Purpose of the Study:

  • To analyze the incidence, clinical characteristics, and outcomes of synchronous and metachronous multiple primary lung cancers.
  • To compare the presentation and survival rates between synchronous and metachronous MPLC in a series of resected lung tumors.

Main Methods:

  • Retrospective analysis of 1980 consecutively resected lung tumors.
  • Classification of MPLC into synchronous (≤6 months) and metachronous (>6 months) based on Martini and Melamed criteria.
  • Evaluation of clinical presentation, tumor location, surgical management, and survival data.

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Main Results:

  • Seventy-five cases (3.78%) were identified as MPLC, comprising 24 synchronous and 51 metachronous.
  • All MPLC cases occurred in male tobacco smokers.
  • Synchronous MPLC presented with symptoms in 66% of cases, compared to 37% for metachronous.
  • Resection of both tumors was performed in 15 synchronous and 19 metachronous cases.
  • No patient with resected synchronous MPLC survived 5 years, versus 20% for resected metachronous MPLC.

Conclusions:

  • Synchronous MPLC appears to represent a more advanced stage of lung cancer.
  • Metachronous MPLC are frequently diagnosed at a late stage, impacting survival outcomes.
  • Further research is needed to improve early detection and treatment strategies for metachronous MPLC.