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The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease
A Eckert1, H Förstl, H Hartmann
1Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany.
Neuroreport
|May 30, 1995
Abstract:
The amplifying effect of beta-amyloid fragment 25-35 (beta A25-35) on the mitogen-induced rise of free intracellular calcium in circulating lymphocytes was strongly reduced in 24 patients with Alzheimer's disease when compared with elderly, non-demented controls. Low beta-amyloid responses were significantly correlated with the presence of the apolipoprotein E epsilon 4 allele, suggesting a dose effect.