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Interleukin-1 beta stimulates phospholipase A2 activity in rat C6 glioma cells
1Department of Neuroscience, Osaka Bioscience Institute, Japan.
Abstract:
Phospholipase A2 activities could be detected in both cytosolic and membrane fractions prepared from rat C6 glioma cells. The activities in both fractions were significantly increased by human recombinant interleukin-1 beta in a dose-dependent manner. Such a stimulation required a long-time exposure over 72 h and was partially inhibited by cycloheximide, a potent protein synthesis inhibitor. These results suggested that interleukin-1 beta may stimulate phospholipase A2 activity through its gene activation.

