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Effect of novel aromatic derivative of GABA on lipid peroxidation in chronically morphinized rats
E Lurie1, A Soloviova, T Alyabieva
1M.V. Lomonosov Institute of Fine Chemical Technology, Moscow 117571, Russia.
Biochemistry and Molecular Biology International
|May 1, 1995
Abstract:
Effect of novel aromatic GABA derivative (AFA) on lipid peroxidation (LP) was studied in the male rats of the Wistar strain. The morphine-received animals had the higher level of LP in blood plasma, decreased level of total antioxidant activity, the increased rate of LP in the ascorbate-induced system in liver homogenate. In the case of AFA administration with morphine, all the above mentioned effects were almost withdrawn.