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[Bone abnormalities and fetal cytomegalovirus infection]
J L Alessandri1, A Breton, A Montbrun
1Service de réanimation néonatale et infantile, CHD Félix-Guyon, Saint-Denis, La Réunion, France.
Summary
Cytomegalovirus (CMV) infection in newborns can cause bone rarefaction, a condition previously associated mainly with congenital rubella. This finding highlights CMV as a significant cause of neonatal bone abnormalities.
Area of Science:
- Neonatology
- Virology
- Pediatric Radiology
Background:
- Congenital viral infections, including rubella and cytomegalovirus (CMV), are known to cause bone rarefaction.
- This study investigates a case of neonatal bone lesions.
Observation:
- A neonate presented with hypotrophy and complex heart defects.
- Skeletal X-rays revealed metaphyseal rarefaction bands in long bones and sclerosis/rarefaction in femora.
- Urine culture confirmed active cytomegalovirus (CMV) infection.
Findings:
- The neonate displayed bone changes typically associated with congenital rubella.
- Cytomegalovirus (CMV) infection was confirmed through urine culture and serology.
- This case demonstrates that CMV infection can manifest with bone lesions similar to rubella.
Implications:
- Neonatal bone changes observed in congenital rubella may also be indicative of cytomegalovirus (CMV) infection.
- This broadens the differential diagnosis for bone abnormalities in newborns.
- Highlights the importance of considering CMV in the workup of neonatal bone lesions.