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[Disorders in sugar utilization by peripheral tissues in lung cancer]
Voprosy Onkologii
|January 1, 1975
Summary
Lung cancer patients often show impaired sugar metabolism in peripheral tissues. Some patients release sugar into the blood, indicating reduced pancreatic islet cell function.
Area of Science:
- Biochemistry
- Oncology
- Endocrinology
Context:
- Investigates metabolic alterations in lung cancer patients.
- Examines peripheral tissue sugar utilization.
- Assesses pancreatic functional activity.
Purpose:
- To determine sugar utilization rates in antebrachial tissues of lung cancer patients.
- To investigate the relationship between lung cancer and peripheral glucose metabolism.
- To assess pancreatic insular apparatus activity in relation to observed metabolic changes.
Summary:
- Arteriovenous difference measurements revealed impaired peripheral tissue metabolism in 70% of 140 lung cancer patients.
- Observed metabolic impairments included reduced sugar utilization and sugar release by tissues into the blood.
- Patients exhibiting sugar release showed reduced pancreatic insular apparatus activity.
Impact:
- Highlights potential metabolic dysregulation in lung cancer.
- Suggests a link between pancreatic function and peripheral tissue metabolism in cancer patients.
- Provides insights into the complex interplay between cancer and glucose homeostasis.