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Burkitt translocation (8;22)(q24;q11) in a patient with multiple myeloma
R M Look1, S W Lim, R R Schreck
1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Cancer Genetics and Cytogenetics
|July 15, 1995
Abstract:
The prevalence of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24% to 63% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1-8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.