[Comparison of short and protracted streptokinase therapy in acute myocardial infarction]

In numerous controlled studies the effectivity of the streptokinase therapy of the acute myocardial infarction is proved by a significant decrease of the early lethality. The main difference of the therapeutic methods lies in the duration of the application of streptokinase. Of the number of patients of an intensive therapy ward for internal diseases comparisons of the results of therapy of one year with short-term lysis (3 hours) are contrasted with one year with protracted lysis therapy (24-72 hours). The findings demonstrated plead for the fact that by means of the short-time lysis may also be achieved good, perhaps even better results. Issuing from the therapeutic mechanisms of the lysis therapy in the sense of a prevention of the formation of thrombi in disturbed microcirculation by the achieved hyperplasminaemia the short-term lysis is to be regarded as optimum introduction of an anticoagulant long-term therapy.