[The effect of sodium prasterone sulfate on lactation]

To study the relationship between sodium prasterone sulfate and lactation, blood samples were collected from 120 cases. Sixty cases were in study group (at different periods: during the 3rd trimester, and 1st, 3rd day postpartum) including 30 cases using 100mg sodium prasterone sulfate, 30 cases (using 200mg sodium prasterone sulfate), 60 cases were in control group. The serum levels of estradiol (E2), prolactin (PRL) and plasma levels of oxytocin (OT) were measured by radioimmunoassay, and the production of breast milk was observed. The results showed no statistically significant difference of serum E2, PRL and plasma OT between (sodium prasterone sulfate) study groups and control groups, and the production of breast milk indicated also no significant difference between the 2 groups. The conclusion is that low-dose sodium prasterone sulfate (200mg/day, 600mg/week) did not affect the production of breast milk.