Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Obstructive sleep apnoea and signal averaged electrocardiogram

S Andreas1, B von Breska, A Schaumann

  • 1Dept of Cardiology and Pneumology, University of Göttingen, Germany.

The European Respiratory Journal
|April 1, 1995
PubMed
Summary

Obstructive sleep apnea (OSA) patients have more ventricular arrhythmias, but this study found no evidence of myocardial injury. Signal-averaged ECGs in OSA patients did not reveal the abnormal heart signals associated with such injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurosurgical treatment of pediatric brain tumors - results from a single center multidisciplinary setup.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2023
Same author

Retrospective single-center historical comparative study between proGAV and proGAV2.0 for surgical revision and implant duration.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2022
Same author

TROPHY registry - status report.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2021
Same author

Endoscopic third ventriculostomy in children with third ventricular pressure gradient and open ventricular outlets on MRI.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2019
Same author

Dynamic cerebellar herniation in Chiari patients during the cardiac cycle evaluated by dynamic magnetic resonance imaging.

Neuroradiology·2019
Same author

Neuroendoscopic lavage for the treatment of CSF infection with hydrocephalus in children.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2018

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Electrophysiology

Background:

  • Obstructive sleep apnea (OSA) is linked to a higher incidence of ventricular arrhythmias.
  • Myocardial injury can alter the signal-averaged electrocardiogram (ECG), indicating potential substrate for arrhythmias.
  • The relationship between OSA, myocardial injury, and arrhythmia substrate requires further investigation.

Purpose of the Study:

  • To investigate if myocardial injury, detectable by signal-averaged ECG, underlies the increased ventricular arrhythmias in obstructive sleep apnea patients.
  • To assess for the presence of late potentials, indicative of arrhythmogenic substrate, in the signal-averaged ECG of OSA patients.

Main Methods:

  • Signal-averaged ECGs were recorded in 23 patients diagnosed with obstructive sleep apnea (OSA) via polysomnography.

Related Experiment Videos

  • Exclusion criteria included coronary heart disease and bundle branch block.
  • Filtered QRS duration, root mean square voltage, and low-amplitude signal duration were analyzed. Echocardiography was performed.

    • Main Results:

    • No patient with OSA exhibited abnormal signal-averaged ECG findings, specifically no late potentials.
    • Mean signal-averaged ECG parameters (QRS duration, RMS voltage, low-amplitude duration) were not significantly different between OSA patients and controls.
    • Despite some patients having significant ventricular arrhythmias (Lown III-IVa), their signal-averaged ECGs were normal.

    Conclusions:

    • Obstructive sleep apnea does not appear to create the myocardial substrate for late potentials as detected by signal-averaged ECG.
    • The increased ventricular arrhythmias in OSA may stem from mechanisms other than the typical substrate identified by signal-averaged ECG analysis.
    • Further research is needed to elucidate the arrhythmogenesis in obstructive sleep apnea.