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Published on: March 20, 2018
1,2,3-Trichloropropane: a multisite carcinogen in rats and mice
R D Irwin1, J K Haseman, S L Eustis
1National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Summary
1,2,3-Trichloropropane (TCP) exposure caused various cancers in rats and mice during a 2-year study. This chemical carcinogen poses risks due to its genotoxicity and links to similar compounds.
Area of Science:
- Toxicology
- Carcinogenesis
- Chemical Safety
Background:
- 1,2,3-Trichloropropane (TCP) was selected for study due to potential human exposure.
- Positive in vitro genotoxicity and carcinogenicity of related chemicals informed the study's focus.
- National Toxicology Program (NTP) conducted comprehensive 2-year toxicology and carcinogenesis assessments.
Purpose of the Study:
- To evaluate the toxicological and carcinogenic potential of 1,2,3-Trichloropropane in rodents.
- To determine dose-response relationships for TCP-induced neoplasms.
- To assess long-term health effects following chronic exposure.
Main Methods:
- F344/N rats and B6C3F1 mice were administered 1,2,3-Trichloropropane (TCP) via oral gavage in corn oil, 5 days per week.
- Dose levels varied: rats received 0, 3, 10, or 30 mg/kg; mice received 0, 6, 20, or 60 mg/kg.
- Study durations were adjusted due to chemical-related neoplasms and reduced survival, with specific termination points for high-dose groups.
Main Results:
- 1,2,3-Trichloropropane (TCP) induced benign and malignant neoplasms at multiple sites in both rats and mice.
- Rats showed increased neoplasms in the oral mucosa, forestomach, kidney, pancreas, and preputial/clitoral glands.
- Mice developed neoplasms in the forestomach, liver, harderian gland, and uterus, with some oral mucosa malignancies.
Conclusions:
- 1,2,3-Trichloropropane (TCP) is a carcinogen in rats and mice, inducing a spectrum of tumors.
- The findings highlight the carcinogenic risk associated with TCP exposure.
- Results support concerns regarding human exposure to this genotoxic chemical.
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