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A controlled multivariate chart review of multiple complex developmental disorder

R J Van der Gaag1, J Buitelaar, E Van den Ban

  • 1Department of Child and Adolescent Psychiatry, University of Utrecht, The Netherlands.

Journal of the American Academy of Child and Adolescent Psychiatry
|August 1, 1995
PubMed
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This study validates criteria for Multiple Complex Developmental Disorder (MCDD), a proposed subgroup within pervasive developmental disorders. Findings support MCDD as a distinct category within autistic spectrum disorders, differentiating it from autistic disorder.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Psychiatry

Background:

  • The classification of pervasive developmental disorders is complex, with ongoing debate regarding distinct diagnostic categories.
  • Multiple Complex Developmental Disorder (MCDD) has been proposed as a specific subgroup within pervasive developmental disorder-not otherwise specified.
  • Validating diagnostic criteria is crucial for accurate diagnosis and effective treatment planning.

Purpose of the Study:

  • To evaluate the utility and validity of proposed criteria for defining Multiple Complex Developmental Disorder (MCDD).
  • To determine if MCDD represents a distinct subgroup within the broader category of pervasive developmental disorders.
  • To explore the relationship between MCDD, autistic disorder, and other developmental disorders.

Main Methods:

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  • Multivariate statistical analyses, including cluster analysis and principal-components analysis, were employed.
  • Data were collected from 105 children diagnosed with MCDD, 32 with autistic disorder, 51 with externalizing disorders, and 56 with internalizing disorders.
  • All participants had an IQ greater than 70 and underwent comprehensive assessment between 1984 and 1991.

Main Results:

  • Cluster analysis results showed strong alignment with existing DSM-III-R diagnostic categories.
  • The analysis did not differentiate between children with emotional/disruptive disorders.
  • Significant differences were found between children with MCDD and autistic disorder across symptom clusters and developmental/environmental factors.

Conclusions:

  • The findings support the distinctiveness of MCDD and its potential inclusion as a separate subcategory in future diagnostic manuals like DSM-V.
  • Results contribute to the nosological understanding of autistic spectrum disorders.
  • Further validation in independent, multicenter samples is recommended to strengthen these conclusions.