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Related Experiment Videos

p53 mutations in benign breast tissue

R Millikan1, B Hulka, A Thor

  • 1Department of Epidemiology, University of North Carolina, Chapel Hill 27599, USA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|September 1, 1995
PubMed
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Investigating molecular markers in benign breast biopsies revealed p53 gene mutations in some cases. Further research is needed to determine if these findings predict invasive breast cancer risk.

Area of Science:

  • Oncology
  • Molecular Pathology
  • Breast Cancer Research

Background:

  • Benign breast biopsies with atypical epithelial proliferation or fibroadenoma may indicate increased invasive breast cancer risk.
  • Molecular markers may offer insights into the malignant potential of nonneoplastic breast tissue.

Purpose of the Study:

  • To investigate the utility of molecular markers (HER-2/neu, p53) in evaluating the malignant potential of benign breast tissue.
  • To determine if HER-2/neu and p53 alterations in benign breast biopsies correlate with future invasive breast cancer development.

Main Methods:

  • Analysis of 60 benign breast biopsies from a cohort of 6,805 women using immunohistochemistry, differential polymerase chain reaction (PCR), and single-strand conformation analysis (SSCA).
  • Assessed HER-2/neu and p53 over-expression, HER-2/neu and PRAD-1 amplification, and p53 gene mutations.

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Main Results:

  • No amplification of HER-2/neu or PRAD-1 was detected.
  • Low-level HER-2/neu immunoreactivity was found in 5 samples; p53 protein immunoreactivity in 14 samples.
  • Point mutations in the p53 gene were identified in 5 samples, with 3 altering the amino acid sequence. Only 2 of these showed p53 overexpression.

Conclusions:

  • The clinical significance of p53 mutations, p53 overexpression, and low-level HER-2/neu expression in benign breast tissue requires further investigation.
  • Additional research is necessary to ascertain if these molecular markers can aid histology in assessing malignant potential of benign breast lesions.