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Related Experiment Videos

Transdermal hormonal replacement therapy with transdermal progestin every second month

R Lindgren1, B Risberg, M Hammar

  • 1Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of Linköping, Sweden.

Maturitas
|June 1, 1995
PubMed
Summary

Spacing progestin therapy every second month during transdermal hormone replacement therapy effectively controlled bleeding and maintained a healthy endometrium in most menopausal women. This approach may offer an alternative to monthly progestin use.

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Area of Science:

  • Reproductive Endocrinology
  • Menopausal Hormone Therapy

Background:

  • Unopposed estrogen therapy can lead to endometrial hyperplasia in menopausal women.
  • Combining estrogen with progestin is crucial for endometrial protection in women with an intact uterus.

Purpose of the Study:

  • To assess the impact of a spaced-out progestin regimen on bleeding control.
  • To evaluate endometrial effects of using progestin every second month during transdermal hormone therapy.

Main Methods:

  • Sixty-eight women on sequential transdermal hormone replacement therapy were studied for 2 years.
  • The regimen involved 6 weeks of estradiol followed by 2 weeks of estradiol with norethisterone acetate.
  • Endometrial biopsies and vaginal ultrasounds were performed annually.

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Main Results:

  • One case of endometrial hyperplasia was diagnosed in the second year; most biopsies showed secretory endometrium.
  • The majority of women experienced a regular bleeding pattern.
  • Vaginal ultrasound did not correlate with bleeding patterns or endometrial histology.

Conclusions:

  • Administering transdermal progestin every second month is a viable alternative to monthly regimens.
  • This spaced-out approach appears safe and effective for endometrial protection and bleeding control.