Related Experiment Videos

Atypical demyelinating lesions in patients with multiple sclerosis

Z Yetkin1, V M Haughton

  • 1Department of Radiology, Medical College of Wisconsin, Milwaukee, USA.

Neuroradiology
|May 1, 1995
PubMed

Insights

We identified a rare, distinctive MRI finding in multiple sclerosis (MS) patients. This "concentric ring" sign on T2 and T1 imaging may indicate new, active MS lesions.

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
  • Characteristic MRI findings are crucial for MS diagnosis and monitoring disease activity.
  • Atypical lesion appearances can pose diagnostic challenges.

Observation:

  • An atypical MRI pattern was observed in 6 out of 132 multiple sclerosis patients.
  • These lesions featured a distinct rim of increased signal intensity on T2-weighted images.
  • A concentric region of higher signal intensity was also noted within these lesions.

Findings:

  • On T1-weighted MRI, these atypical lesions presented as areas of low signal intensity.
  • Often, a rim of contrast enhancement or increased signal intensity was visible on T1-weighted images.
  • These specific MRI appearances were predominantly associated with new, actively evolving MS lesions.

Implications:

  • This atypical MRI finding may represent a specific pattern of active demyelination or inflammation in MS.
  • Recognition of this pattern could aid in the early diagnosis and characterization of MS activity.
  • Further research is warranted to understand the pathological basis and clinical significance of these concentric MRI lesions in multiple sclerosis.

Related Concept Videos