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Updated: Feb 12, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
[A resonance mechanism of immunomodulation by weak pulse currents (experimental study)]
Abstract:
The specific features of weak pulse current effects on immune rosette-formation in mice have been investigated. It has been demonstrated that there is a possible resonance (in the range of narrow values) mechanism of immunomodulation in mice with weak pulse currents. The parameters of this effect have been defined. These include 543 kHz, triangular or quadratic signal form with 5-10-min exposure just after animal immunization for immunostimulation and 4 hours later for immunosuppression. The resonance mechanism is one of the determinants when low-intensity factors have an influence on the body, which makes one use therapeutically safe and weak physical and other factors.
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