Urinary concentration of a specific peptide of type I collagen of bone (CrossLaps): correlation to hydroxyproline

Urinary bone resorption markers, CrossLaps and hydroxyproline are compared in a non-selected group of 93 women. The correlation between CrossLaps and hydroxyproline is satisfactory. The r value is 0.79. Furthermore, it is investigated whether CrossLaps can substitute for hydroxyproline in the estimation of bone loss, using a model based on the combination of several biochemical markers. The results indicate that the two systems reflect related or parallel events, and show that CrossLaps is suitable for use in a normal clinical chemistry laboratory.