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Effects of cis-trans viability selection on some two-locus models
M Nordborg1, I R Franklin, M W Feldman
1Department of Biological Sciences, Stanford University, California 94305-5020, USA.
Theoretical Population Biology
|June 1, 1995
Summary
Differences in fitness between cis and trans configurations can create significant linkage disequilibrium in two-locus viability models. Even minor selective differences can generate high levels of linkage disequilibrium, impacting gene frequency.
Area of Science:
- Population genetics
- Evolutionary biology
- Quantitative genetics
Background:
- Traditional two-locus viability models often assume equal fitness for cis and trans heterozygotes.
- This assumption is frequently violated for polymorphic sites within the same gene.
Purpose of the Study:
- To investigate the impact of cis-trans viability differences on deterministic two-locus models.
- To analyze the quantitative and qualitative effects of these fitness variations.
Main Methods:
- Development and analysis of deterministic two-locus viability models.
- Incorporation of cis-trans specific fitness differences for double heterozygotes.
Main Results:
- Identified the potential for two asymmetric equilibria with similar linkage disequilibrium but differing gene frequencies.
- Demonstrated that small selective differences in cis and trans configurations can generate substantial linkage disequilibrium.
Conclusions:
- Selective interactions between polymorphic sites are strongly associated with high linkage disequilibrium.
- Linkage equilibrium between two polymorphic sites suggests potential selective neutrality for one or both sites.