[Physicochemical incompatibility of injectable drugs: practical considerations]

Preservatives and additives are needed to prepare stable solutions for injection. They may provoke physiochemical reactions when these solutions are mixed. End-products may be either inactive or toxic to the patient. Information on allowed mixtures is scarce. Compatibility analyses are difficult to perform in a short time and are usually expensive. The best way would be to inject the drugs separately with 50 or 100 ml infusions. Moreover, some laboratories supply prepared infusion solutions such as buflomedil, pefloxacine, metronidazole.