Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The focal cone electroretinogram

S Yamamoto1, P Gouras, R Lopez

  • 1Department of Ophthalmology, Columbia University, New York, NY 10032, USA.

Vision Research
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel organelles in primate retinal epithelium.

Micron (Oxford, England : 1993)·2016
Same author

Bestrophin detected in the basal membrane of the retinal epithelium and drusen of monkeys with drusenoid maculopathy.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2009
Same author

Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy.

Gene therapy·2008
Same author

Behavior of retinal epithelium to bleb detachment versus retinectomy.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2006
Same author

Later years at Columbia.

Experimental eye research·2004
Same author

Genotyping microarray (gene chip) for the ABCR (ABCA4) gene.

Human mutation·2003
Same journal

Computational and mathematical models in vision: Quantitative approaches to understanding visual perception.

Vision research·2026
Same journal

Complex interactions between lightness, chroma, and hue in color ensemble perception.

Vision research·2026
Same journal

Driving with autism spectrum disorder: Exploring the impact of tactile hazard warnings on gaze behavior and hazard responses.

Vision research·2026
Same journal

Early visual processing in adults with ADHD: evidence from contrast sensitivity, spatial integration, and external noise.

Vision research·2026
Same journal

Pupil reflexes generate the peripheral drift illusion due to ON/OFF motion responses.

Vision research·2026
Same journal

Perceived direction of glass patterns can flip by 90°: A neural model.

Vision research·2026
See all related articles

The focal cone electroretinogram (ERG) in monkey retinas shows distinct components, with the fovea exhibiting a slower, longer wavelength-sensitive response compared to peripheral areas. This difference highlights unique cone bipolar cell interactions near the fovea.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Retinal Physiology

Background:

  • The focal electroretinogram (ERG) is a key tool for assessing retinal function.
  • Cone ERGs specifically evaluate the function of cone photoreceptors, crucial for color and detailed vision.

Purpose of the Study:

  • To investigate the characteristics of the focal cone electroretinogram (ERG) at different retinal eccentricities in monkey retinas.
  • To compare foveal and perifoveal cone ERG responses and identify underlying mechanisms.

Main Methods:

  • Examined focal cone ERGs using 3-degree laser pulses (544 and 633 nm) on a rod-saturating white field in monkey retinas.
  • Studied cone ERGs at various eccentricities from the fovea, comparing them with full-field and intraretinal ERGs.

Related Experiment Videos

Main Results:

  • The cone ERG amplitude is maximal at the fovea.
  • Two components were identified in the on- (b-wave) and off- (d-wave) responses: a slower, longer wavelength-sensitive, foveally-oriented component and a faster component.
  • Foveal cone ERGs are larger and slower than peripheral ERGs, with the slowness attributed to a foveal subcomponent with greater long-wavelength sensitivity.

Conclusions:

  • The foveal cone ERG exhibits unique properties, including slower and longer wavelength-sensitive responses compared to peripheral retina.
  • These differences may stem from specialized L-M cone bipolar systems or cone interactions concentrated near the fovea.