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[Oxygen transport in shock (author's transl)]
Bulletin De Physio-Pathologie Respiratoire
|September 1, 1975
Summary
Shock impairs oxygen transport from lungs to mitochondria, causing hypoxemia and cellular dysfunction. This review details how shock disrupts oxygen delivery and utilization, leading to tissue hypoxia and anaerobic metabolism.
Area of Science:
- Physiology
- Pathophysiology
Context:
- Shock states significantly disrupt oxygen transport.
- Understanding these disruptions is crucial for managing critically ill patients.
Purpose:
- To review the functional consequences of shock on oxygen transport.
- To elucidate the mechanisms of impaired oxygen delivery and utilization.
Summary:
- Shock compromises pulmonary gas exchange by altering ventilation/perfusion ratios and damaging the air-blood barrier.
- Reduced oxygen delivery to tissues results from decreased cardiac output or altered circulatory distribution, exacerbating tissue hypoxia.
- Impaired microcirculation, rheologic changes, and intravascular coagulation further hinder oxygen diffusion and intracellular transport, ultimately leading to mitochondrial dysfunction and anaerobic metabolism.
Impact:
- Provides a comprehensive overview of shock-induced oxygen transport defects.
- Highlights the role of hyperlactacidemia as an indicator of oxygen debt.