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Synthesis and antimicrobial evaluation of new quinazolinone derivatives
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Beyazit, Turkey.
Farmaco (Societa Chimica Italiana : 1989)
|July 1, 1995
Abstract:
A new hydrazide, 3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetic acid hydrazide 3 was synthesized by the reaction of 3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetic acid ethyl ester with hydrazine hydrate. Subsequent treatment of 3 with aromatic aldehydes and alkyl/arylisothiocyanates furnished the corresponding hydrazones 4a-f and the thiosemicarbazides 5a-e, respectively. Cyclocondensation of 5a-e in sulfuric acid yielded the thiadiazoles 6a-d. All the synthesized compounds were tested for in vitro antimicrobial action against some aerobic bacteria and C. albicans.