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Effects of different antihypertensive drugs on plasma fibrinogen in hypertensive patients

R Fogari1, A Zoppi, G D Malamani

  • 1Department of Internal Medicine and Therapeutics, University of Pavia, Italy.

British Journal of Clinical Pharmacology
|May 1, 1995
PubMed

Insights

Lisinopril effectively lowers plasma fibrinogen levels in hypertensive patients, unlike atenolol, amlodipine, or hydrochlorothiazide. This study highlights how different antihypertensive drugs impact metabolic profiles and overall patient risk.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Metabolic Studies

Background:

  • Essential hypertension is a common condition requiring effective management.
  • Antihypertensive medications are known to have various systemic effects beyond blood pressure reduction.
  • The impact of different antihypertensive drug classes on plasma fibrinogen and metabolic parameters requires further elucidation.

Purpose of the Study:

  • To evaluate the effect of four different antihypertensive drugs on plasma fibrinogen levels.
  • To compare the metabolic effects of amlodipine, atenolol, hydrochlorothiazide, and lisinopril in hypertensive patients.

Main Methods:

  • A randomized trial involving 118 male patients with mild to moderate essential hypertension.
  • Treatment with amlodipine, atenolol, hydrochlorothiazide, or lisinopril once daily for 8 weeks.
  • Comprehensive evaluation of blood pressure, heart rate, plasma fibrinogen, lipids, glucose, uric acid, creatinine, and potassium before and after treatment.

Main Results:

  • All four drugs significantly reduced blood pressure; lisinopril, amlodipine, and atenolol showed greater efficacy than hydrochlorothiazide.
  • Lisinopril significantly decreased plasma fibrinogen levels by 11.2%, particularly in smokers.
  • Hydrochlorothiazide adversely affected lipid profiles, glucose, uric acid, and potassium levels, while lisinopril improved HDL-C and decreased TC and LDL-C.

Conclusions:

  • Lisinopril demonstrates a significant fibrinogen-lowering effect in hypertensive individuals.
  • Different classes of antihypertensive drugs exert distinct metabolic effects.
  • These varied metabolic impacts can influence the overall cardiovascular risk profile of patients with hypertension.

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