Related Experiment Videos
Bullous pemphigoid successfully controlled by tetracycline and nicotinamide
D N Kolbach1, J J Remme, W H Bos
1Department of Dermatology, Academisch Ziekenhuis, Groningen, Velsen, The Netherlands.
The British Journal of Dermatology
|July 1, 1995
Abstract:
In 1986, Berk and Lorincz reported the efficacy of tetracycline and nicotinamide in the treatment of bullous pemphigoid (BP). In the present study of seven patients with BP, we found that a regimen of 2 g tetracycline combined with 2 g nicotinamide daily was effective in clearing the skin lesions. Total remission was achieved within 6-8 weeks, after which the dose was gradually tapered. The mean duration of therapy was 7 months. No effect on the titre of antibasement membrane antibodies was observed. The mode of action of this therapy is unknown.