Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinal detachment induces massive immediate reorganization in visual cortex

L M Schmid1, M G Rosa, M B Calford

  • 1Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia.

Neuroreport
|June 19, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: studies in a rat stroke model.

International journal of stroke : official journal of the International Stroke Society·2013
Same author

Short-duration hypothermia after ischemic stroke prevents delayed intracranial pressure rise.

International journal of stroke : official journal of the International Stroke Society·2013
Same author

Cellular distribution of the GABAA receptor-modulating 3alpha-hydroxy, 5alpha-reduced pregnane steroids in the adult rat brain.

Journal of neuroendocrinology·2007
Same author

A consensus statement on osseoperception.

Clinical and experimental pharmacology & physiology·2005
Same author

Laminar differences in plasticity in area 17 following retinal lesions in kittens or adult cats.

The European journal of neuroscience·2003
Same author

Topographic reorganization in area 18 of adult cats following circumscribed monocular retinal lesions in adolescence.

The Journal of physiology·2002

Induced retinal detachment in cats rapidly altered visual cortex maps. Neurons quickly adapted, showing large receptive fields on intact retina, demonstrating cortical plasticity.

Area of Science:

  • Neuroscience
  • Visual System Research
  • Cortical Plasticity Studies

Background:

  • The adult visual cortex was traditionally considered relatively fixed.
  • Understanding rapid neural map reorganization is crucial for visual neuroscience.

Purpose of the Study:

  • To investigate the capacity for rapid map reorganization in the adult cat's primary visual cortex.
  • To explore the mechanisms underlying swift neural adaptation following retinal injury.

Main Methods:

  • Induction of monocular retinal detachment in adult cats.
  • Electrophysiological recording of neuronal receptive fields in the primary visual cortex.
  • Mapping of retinotopic representations before and after induced detachment.

Main Results:

Related Experiment Videos

  • Large inactive retinal regions were created by monocular retinal detachment.
  • Within hours, neurons in the visual cortex exhibited large receptive fields shifted to intact retina.
  • Receptive field shifts up to 9 mm were observed, indicating significant retinotopic map changes.
  • The contralateral eye's visual map remained unaffected, suggesting specific adaptation mechanisms.

Conclusions:

  • The adult visual cortex demonstrates remarkable and rapid plasticity.
  • Pre-existing neural circuits can support swift reorganization of visual maps.
  • This study provides evidence for rapid functional adaptation in the visual cortex following retinal damage.