Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluid delivery from infusion-pump syringes

J L Carl1, B L Erstad, J E Murphy

  • 1Stanford Health Services, Palo Alto, CA, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost-effectiveness analysis of adding omega-3 or vitamin D supplementation to standard therapy in treating painful crises of pediatric sickle cell disease patients.

European review for medical and pharmacological sciences·2022
Same author

Comparative effectiveness of adding Omega-3 or Vitamin D to standard therapy in preventing and treating episodes of painful crisis in pediatric sickle cell patients.

European review for medical and pharmacological sciences·2022
Same author

A first-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-06741086, an anti-tissue factor pathway inhibitor mAb, in healthy volunteers.

Journal of thrombosis and haemostasis : JTH·2018
Same author

Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report.

Journal of clinical pharmacy and therapeutics·2018
Same author

Mitochondrial gene expression changes in cultured human skin cells following simulated sunlight irradiation.

Journal of photochemistry and photobiology. B, Biology·2018
Same author

The Impact of Pathologic Complete Response in Patients with Neoadjuvantly Treated Locally Advanced Rectal Cancer-a Large Single-Center Experience.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2017
Same journal

Recent and anticipated novel drug approvals (Q2 2026 through Q1 2027).

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same journal

Optimizing transitions from direct factor Xa inhibitors to unfractionated heparin therapy.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same journal

Impact of pharmacist involvement on hospital sepsis response teams.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same journal

Attributes of centralized health-system specialty pharmacy clinics: A scoping review using the Donabedian model.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same journal

Zoliflodacin: A novel single-dose oral antibiotic for uncomplicated urogenital gonorrhea.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same journal

Implementation of a paid apprenticeship-model pharmacy technician training program.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
See all related articles

Infusion pump syringes showed significant variations in fluid delivery rates and bolus volumes, impacting accuracy. Syringe accuracy varied over time and with initial fluid volumes, affecting medication delivery precision.

Area of Science:

  • Medical Devices
  • Pharmacology
  • Biomedical Engineering

Background:

  • Accurate fluid delivery is critical for patient safety and therapeutic efficacy.
  • Small-volume infusion pumps are widely used for precise medication administration.
  • Variability in syringe performance can compromise drug delivery accuracy.

Purpose of the Study:

  • To compare the fluid delivery accuracy of five different small-volume infusion pump syringes.
  • To evaluate syringe performance under various continuous and bolus delivery settings.
  • To identify potential sources of error in infusion pump syringe performance.

Main Methods:

  • Five 30-mL syringes from different manufacturers were tested in two infusion pumps (Lifecare PCA Plus II and Stratofuse PCA).

Related Experiment Videos

  • Syringes were evaluated at continuous delivery rates of 1 mL/hr and 3 mL/hr, and for 1-mL bolus deliveries after removing 0, 5, 15, and 25 mL.
  • Delivered fluid volumes were measured by weight and calculated using specific gravity.

    • Main Results:

    • Significant differences in fluid delivery volumes were observed among syringes during the first hour at both 1 mL/hr and 3 mL/hr rates.
    • Delivery accuracy varied over time for most syringes tested.
    • Bolus volume accuracy was inconsistent, particularly after infusing 0 or 5 mL, but improved with larger volumes.

    Conclusions:

    • The performance of small-volume infusion pump syringes is not uniform, leading to potential inaccuracies in medication delivery.
    • Syringe selection and usage protocols should consider the observed variability in delivery rates and bolus volumes.
    • Further research is needed to optimize syringe design and infusion pump algorithms for enhanced accuracy.