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Published on: November 16, 2011
Transforming growth factor-alpha expression in in situ epidermal neoplasia
J J Grant1, G Howes, P H McKee
1Army Histology Registry, Royal Army Medical College, Millbank, London, UK.
Abstract:
Twenty cases of solar keratosis and 15 cases of Bowen's disease were investigated for the expression of transforming growth factor alpha (TGF-alpha) by an indirect immunoperoxidase technique using monoclonal antibody TGF-alpha AB-2 in formalin-fixed wax-embedded tissue. Twelve cases (60%) of solar keratosis and 13 cases (86%) of Bowen's disease showed marked overexpression of TGF-alpha in both membranous and cytoplasmic distributions. This suggests that overexpression of TGF-alpha may play an important role in the evolution of these two neoplastic conditions.
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