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Related Experiment Videos

Primary cutaneous cryptococcosis and Cryptococcus neoformans serotype D

W Naka1, M Masuda, A Konohana

  • 1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Clinical and Experimental Dermatology
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

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A healthy woman experienced a rare skin infection, primary cutaneous cryptococcosis, caused by Cryptococcus neoformans. The infection resolved spontaneously without antifungal treatment, suggesting this specific fungal strain may cause localized skin disease.

Area of Science:

  • Medical Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Primary cutaneous cryptococcosis is a rare fungal infection.
  • Cryptococcus neoformans is an opportunistic yeast pathogen.
  • Certain serotypes of C. neoformans are associated with specific clinical presentations.

Observation:

  • A 73-year-old Japanese woman presented with a 2-week history of an erythematous, ulcerated skin lesion on her cheek following an injury.
  • Physical examination revealed no regional lymphadenopathy, and chest X-rays were normal.
  • Histopathology showed granulomatous inflammation with Cryptococcus neoformans identified via Periodic acid Schiff and immunoperoxidase staining.

Findings:

  • The causative agent was identified as Cryptococcus neoformans var. neoformans serotype D.

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  • The patient's cutaneous lesions healed spontaneously within one month without antifungal therapy.
  • Literature suggests serotype D C. neoformans may predominantly cause cutaneous manifestations without systemic dissemination.

    • Implications:

    • This case highlights the potential for localized cutaneous disease from Cryptococcus neoformans serotype D.
    • Spontaneous resolution of primary cutaneous cryptococcosis is possible, particularly with this serotype.
    • Further research into the clinical behavior of different Cryptococcus neoformans serotypes in cutaneous infections is warranted.